Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer.

Wang, Guan; Niu, Xiaojia; Zhang, Wenbo; Caldwell, J Timothy; Edwards, Holly; Chen, Wei; Taub, Jeffrey W; Zhao, Lijing; Ge, Yubin

Wang, Guan; Niu, Xiaojia; Zhang, Wenbo; Caldwell, J Timothy; Edwards, Holly; Chen, Wei; Taub, Jeffrey W; Zhao, Lijing; Ge, Yubin.

Afiliação

Wang G; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA.
Niu X; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China.
Zhang W; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China.
Caldwell JT; MD/PhD Program, Wayne State University School of Medicine, Detroit, MI, USA; Cancer Biology Program, Wayne State University School of Medicine, Detroit, MI, USA.
Edwards H; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.
Chen W; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
Taub JW; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA; Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan, Detro
Zhao L; Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, China. Electronic address: zhao_lj@jlu.edu.cn.
Ge Y; National Engineering Laboratory for AIDS Vaccine, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, China; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeuti

Cancer Lett ; 356(2 Pt B): 656-68, 2015 Jan 28.

Article em En | MEDLINE | ID: mdl-25458954

Assuntos

Apoptose/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Sinergismo Farmacológico; Inibidores de Histona Desacetilases/farmacologia; Ácidos Hidroxâmicos/farmacologia; Indóis/farmacologia; Neoplasias Pancreáticas/tratamento farmacológico; Pirazóis/farmacologia; Pirimidinas/farmacologia; Animais; Western Blotting; Ciclo Celular; Proteínas de Ciclo Celular/antagonistas & inibidores; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; Dano ao DNA/efeitos dos fármacos; Interações Medicamentosas; Feminino; Humanos; Técnicas Imunoenzimáticas; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Proteínas Nucleares/antagonistas & inibidores; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Neoplasias Pancreáticas/metabolismo; Neoplasias Pancreáticas/patologia; Panobinostat; Proteínas Tirosina Quinases/antagonistas & inibidores; Proteínas Tirosina Quinases/genética; Proteínas Tirosina Quinases/metabolismo; Pirimidinonas; RNA Mensageiro/genética; RNA Interferente Pequeno/genética; Reação em Cadeia da Polimerase em Tempo Real; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

CHK1; Drug combination; MK-1775; Pancreatic cancer; Panobinostat

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Pirazóis / Pirimidinas / Apoptose / Proliferação de Células / Sinergismo Farmacológico / Inibidores de Histona Desacetilases / Ácidos Hidroxâmicos / Indóis Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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