Non-enzymatic cyclic oxygenated metabolites of adrenic, docosahexaenoic, eicosapentaenoic and α-linolenic acids; bioactivities and potential use as biomarkers.
Biochim Biophys Acta
; 1851(4): 446-55, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25463478
ABSTRACT
Cyclic oxygenated metabolites are formed in vivo through non-enzymatic free radical reaction of n-6 and n-3 polyunsaturated fatty acids (PUFAs) such as arachidonic (ARA C204 n-6), adrenic (AdA 224 n-6), α-linolenic (ALA 183 n-3), eicosapentaenoic (EPA 205 n-3) and docosahexaenoic (DHA 226 n-3) acids. These cyclic compounds are known as isoprostanes, neuroprostanes, dihomo-isoprostanes and phytoprostanes. Evidence has emerged for their use as biomarkers of oxidative stress and, more recently, the n-3PUFA-derived compounds have been shown to mediate bioactivities as secondary messengers. Accordingly, this review will focus on the cyclic oxygenated metabolites generated from AdA, ALA, EPA and DHA. This article is part of a Special Issue entitled "Oxygenated metabolism of PUFA analysis and biological relevance".
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Eicosapentaenoico
/
Ácidos Docosa-Hexaenoicos
/
Ácido alfa-Linolênico
/
Estresse Oxidativo
/
Ácidos Graxos Insaturados
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article