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Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextromethorphan derivatives as non-competitive inhibitors of α3ß4 nicotinic acetylcholine receptor.
Jozwiak, Krzysztof; Targowska-Duda, Katarzyna M; Kaczor, Agnieszka A; Kozak, Joanna; Ligeza, Agnieszka; Szacon, Elzbieta; Wrobel, Tomasz M; Budzynska, Barbara; Biala, Grazyna; Fornal, Emilia; Poso, Antti; Wainer, Irving W; Matosiuk, Dariusz.
Afiliação
  • Jozwiak K; Department of Chemistry, Laboratory of Medicinal Chemistry and Neuroengineering, Medical University of Lublin, 4a Chodzki St., PL-20093 Lublin, Poland.
  • Targowska-Duda KM; Department of Chemistry, Laboratory of Medicinal Chemistry and Neuroengineering, Medical University of Lublin, 4a Chodzki St., PL-20093 Lublin, Poland.
  • Kaczor AA; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division of Medical Analytics, 4a Chodzki St., PL-20093 Lublin, Poland; School of Pharmacy, University of Eastern Finland, Yliopistonranta 1, PO Box 1627, FI-70211 Kuopio
  • Kozak J; Department of Chemistry, Laboratory of Medicinal Chemistry and Neuroengineering, Medical University of Lublin, 4a Chodzki St., PL-20093 Lublin, Poland; Department of Anatomy, Medical University of Lublin, 4 Jaczewskiego St., PL-20090 Lublin, Poland.
  • Ligeza A; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division of Medical Analytics, 4a Chodzki St., PL-20093 Lublin, Poland.
  • Szacon E; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division of Medical Analytics, 4a Chodzki St., PL-20093 Lublin, Poland.
  • Wrobel TM; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division of Medical Analytics, 4a Chodzki St., PL-20093 Lublin, Poland.
  • Budzynska B; Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 4a Chodzki St., PL-20093 Lublin, Poland.
  • Biala G; Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, 4a Chodzki St., PL-20093 Lublin, Poland.
  • Fornal E; Department of Chemistry, Catholic University of Lublin, al. Krasnicka 102, PL-20718 Lublin, Poland.
  • Poso A; School of Pharmacy, University of Eastern Finland, Yliopistonranta 1, PO Box 1627, FI-70211 Kuopio, Finland.
  • Wainer IW; Laboratory of Clinical Investigation, Division of Intramural Research Programs, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
  • Matosiuk D; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab, Faculty of Pharmacy with Division of Medical Analytics, 4a Chodzki St., PL-20093 Lublin, Poland. Electronic address: darek.matosiuk@umlub.pl.
Bioorg Med Chem ; 22(24): 6846-56, 2014 Dec 15.
Article em En | MEDLINE | ID: mdl-25464883
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Nicotínicos / Antagonistas Nicotínicos / Dextrometorfano Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Nicotínicos / Antagonistas Nicotínicos / Dextrometorfano Limite: Animals Idioma: En Ano de publicação: 2014 Tipo de documento: Article