P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study.

Abdulqawi, Rayid; Dockry, Rachel; Holt, Kimberley; Layton, Gary; McCarthy, Bruce G; Ford, Anthony P; Smith, Jaclyn A

Abdulqawi, Rayid; Dockry, Rachel; Holt, Kimberley; Layton, Gary; McCarthy, Bruce G; Ford, Anthony P; Smith, Jaclyn A.

Afiliação

Abdulqawi R; Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; University Hospital of South Manchester, Education and Research Centre, University Hospital of South Manchester, Manchester, UK.
Dockry R; Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; University Hospital of South Manchester, Education and Research Centre, University Hospital of South Manchester, Manchester, UK.
Holt K; Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; University Hospital of South Manchester, Education and Research Centre, University Hospital of South Manchester, Manchester, UK.
Layton G; ParamStat Ltd, Ash, UK.
McCarthy BG; Afferent Pharmaceuticals, San Mateo, CA, USA.
Ford AP; Afferent Pharmaceuticals, San Mateo, CA, USA.
Smith JA; Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; University Hospital of South Manchester, Education and Research Centre, University Hospital of South Manchester, Manchester, UK. Ele

Lancet ; 385(9974): 1198-205, 2015 Mar 28.

Article em En | MEDLINE | ID: mdl-25467586

Assuntos

Antitussígenos/uso terapêutico; Tosse/tratamento farmacológico; Antagonistas do Receptor Purinérgico P2X/uso terapêutico; Adulto; Idoso; Antitussígenos/efeitos adversos; Doença Crônica; Ritmo Circadiano; Estudos Cross-Over; Método Duplo-Cego; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Antagonistas do Receptor Purinérgico P2X/efeitos adversos; Pirimidinas/efeitos adversos; Pirimidinas/uso terapêutico; Índice de Gravidade de Doença; Sulfonamidas; Resultado do Tratamento; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antitussígenos / Tosse / Antagonistas do Receptor Purinérgico P2X Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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