RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly.

Zhang, Pu; Bai, Huiyuan; Fu, Changliang; Chen, Feng; Zeng, Panying; Wu, Chengxiang; Ye, Qichao; Dong, Cheng; Song, Yang; Song, Erqun

Zhang, Pu; Bai, Huiyuan; Fu, Changliang; Chen, Feng; Zeng, Panying; Wu, Chengxiang; Ye, Qichao; Dong, Cheng; Song, Yang; Song, Erqun.

Afiliação

Zhang P; College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China; Department of Bioengineering, Pennsylvania State University, University Park, PA 16801, USA. Electronic address: pxz122@swu.edu.cn.
Bai H; College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Fu C; Department of Bioengineering, Pennsylvania State University, University Park, PA 16801, USA.
Chen F; College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Zeng P; College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Wu C; College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Ye Q; College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Dong C; Department of Bioengineering, Pennsylvania State University, University Park, PA 16801, USA.
Song Y; College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Song E; College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.

Biochem Biophys Res Commun ; 459(1): 1-9, 2015 Mar 27.

Article em En | MEDLINE | ID: mdl-25475728

Assuntos

Junções Aderentes/metabolismo; Proteínas Ativadoras de GTPase/metabolismo; Melanoma/patologia; Migração Transendotelial e Transepitelial; Linhagem Celular Tumoral; Movimento Celular; Células Endoteliais/metabolismo; Quinase 1 de Adesão Focal/metabolismo; Adesões Focais/metabolismo; Proteínas Ativadoras de GTPase/genética; Células Endoteliais da Veia Umbilical Humana; Humanos; Melanoma/metabolismo; Mutação; Paxilina/metabolismo; Fosforilação; Proteínas Tirosina Quinases/metabolismo; Proteína rhoA de Ligação ao GTP/metabolismo

Palavras-chave

Actin; Endothelial junction; FAK; Paxillin; RacGAP1; RhoA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Ativadoras de GTPase / Junções Aderentes / Migração Transendotelial e Transepitelial / Melanoma Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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