Receptor-mediated stimulation of inositol phospholipid hydrolysis in human brain.
Eur J Pharmacol
; 160(2): 299-301, 1989 Jan 31.
Article
em En
| MEDLINE
| ID: mdl-2547631
ABSTRACT
Stimulation of inositol phospholipid hydrolysis by transmitter receptor agonists was studied in slices from the occipital, temporal and cerebellar cortex that were surgically removed from three patients during ablation of brain tumors. Norepinephrine and the muscarinic acetylcholine agonist carbamylcholine increased the content of [3H]inositol monophosphate (InsP) in all the regions examined, whereas the glutamate receptor agonist quisqualate was effective only in the cerebellar slices. These results provide evidence that neurotransmitter receptors are coupled to inositol phospholipid hydrolysis in human brain tissue.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilinositóis
/
Encéfalo
/
Receptores de Superfície Celular
Limite:
Adult
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article