Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway.
Autophagy
; 11(1): 46-59, 2015.
Article
em En
| MEDLINE
| ID: mdl-25484077
Palavras-chave
3MA, 3-methyladenine; CQ, chloroquine; CR, caloric restriction; GOT1/AST, glutamic-oxaloacetic transaminase 1, soluble; GPT/ALT, glutamic-pyruvate transaminase (alanine aminotransferase); IPGTTs, intraperitoneal glucose tolerance tests; MTOR, mechanistic target of rapamycin; Met, metformin; NAFLD, nonalcoholic fatty liver disease; OA, oleic acid; ORO, Oil Red O; PRKA; PRKA, protein kinase, AMP-activated; SIRT1; SIRT1, sirtuin 1; T-CHO, total cholesterol; TG, triglyceride; autophagy; hepatoseatosis; metformin; siRNA, short interfering RNA
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Transdução de Sinais
/
Proteínas Quinases Ativadas por AMP
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Fígado Gorduroso
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Sirtuína 1
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Metformina
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article