Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD.
Autophagy
; 10(11): 1989-2005, 2014.
Article
em En
| MEDLINE
| ID: mdl-25484094
Palavras-chave
3-MA, 3-methyladenine; ACTB, ß-actin; AMD, age-related macular degeneration; APOE4, apolipoprotein E4; FACS, fluorescence-activated cell sorting; FBS, fetal bovine serum; GFP, green fluorescent protein; GSH, glutathione, reduced; GSSG, glutathione, oxidized; H2O2, hydrogen peroxide; HFC, high fat, cholesterol-enriched diet; LC3, microtubule-associated protein 1 light chain 3; MMP, mitochondrial membrane potential; MTT, 3-(4 5-dimethylthiazol-3-yl)-2, 5-diphenyl tetrazolium bromide; ND, normal (rodent) diet; POS, photoreceptor outer segments; ROS, reactive oxygen species; RPE; RPE, retinal pigmented epithelium; SOD2/MnSOD, superoxide dismutase 2, mitochondrial; UPS, ubiquitin-proteasome system; age-related macular degeneration; aging; autophagy; oxidative stress
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Estresse Oxidativo
/
Epitélio Pigmentado da Retina
/
Degeneração Macular
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article