Gut hormones of preterm infants with abdominal symptoms and hypothyroxinemia.
Pediatr Int
; 57(4): 614-9, 2015 Aug.
Article
em En
| MEDLINE
| ID: mdl-25488334
ABSTRACT
BACKGROUND:
The pathogenesis of abdominal symptoms in premature infants with hypothyroxinemia is not understood; therefore, we investigated changes in gut hormones before and after levothyroxine sodium (T4-Na) supplementation in preterm infants with abdominal symptoms and hypothyroxinemia.METHODS:
In eight preterm study subjects and 14 gestational age-matched controls, fasting serum concentration of leptin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide, insulin, amylin and ghrelin was measured using a bead array system.RESULTS:
Serum GLP-1, GIP and PYY in the subjects before T4-Na supplementation were lower than in controls at age 2 weeks. After improvement of abdominal symptoms and free thyroxine, serum levels of the three gut hormones in the subjects were increased and were not different from those in the control patients.CONCLUSIONS:
In preterm infants with abdominal symptoms, serum GLP-1, GIP and PYY might be related to thyroid function.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiroxina
/
Recém-Nascido Prematuro
/
Hormônios Gastrointestinais
/
Doenças do Prematuro
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article