Automated two-point dixon screening for the evaluation of hepatic steatosis and siderosis: comparison with R2-relaxometry and chemical shift-based sequences.
Eur Radiol
; 25(5): 1356-65, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25501270
ABSTRACT
OBJECTIVES:
To evaluate the automated two-point Dixon screening sequence for the detection and estimated quantification of hepatic iron and fat compared with standard sequences as a reference.METHODS:
One hundred and two patients with suspected diffuse liver disease were included in this prospective study. The following MRI protocol was used 3D-T1-weighted opposed- and in-phase gradient echo with two-point Dixon reconstruction and dual-ratio signal discrimination algorithm ("screening" sequence); fat-saturated, multi-gradient-echo sequence with 12 echoes; gradient-echo T1 FLASH opposed- and in-phase. Bland-Altman plots were generated and correlation coefficients were calculated to compare the sequences.RESULTS:
The screening sequence diagnosed fat in 33, iron in 35 and a combination of both in 4 patients. Correlation between R2* values of the screening sequence and the standard relaxometry was excellent (r = 0.988). A slightly lower correlation (r = 0.978) was found between the fat fraction of the screening sequence and the standard sequence. Bland-Altman revealed systematically lower R2* values obtained from the screening sequence and higher fat fraction values obtained with the standard sequence with a rather high variability in agreement.CONCLUSIONS:
The screening sequence is a promising method with fast diagnosis of the predominant liver disease. It is capable of estimating the amount of hepatic fat and iron comparable to standard methods. KEY POINTS ⢠MRI plays a major role in the clarification of diffuse liver disease. ⢠The screening sequence was introduced for the assessment of diffuse liver disease. ⢠It is a fast and automated algorithm for the evaluation of hepatic iron and fat. ⢠It is capable of estimating the amount of hepatic fat and iron.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Processamento de Imagem Assistida por Computador
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Imageamento por Ressonância Magnética
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Siderose
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Fígado Gorduroso
Tipo de estudo:
Diagnostic_studies
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Guideline
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Observational_studies
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Screening_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article