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Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence.
Osman, Abdullah A; Monroe, Marcus M; Ortega Alves, Marcus V; Patel, Ameeta A; Katsonis, Panagiotis; Fitzgerald, Alison L; Neskey, David M; Frederick, Mitchell J; Woo, Sang Hyeok; Caulin, Carlos; Hsu, Teng-Kuei; McDonald, Thomas O; Kimmel, Marek; Meyn, Raymond E; Lichtarge, Olivier; Myers, Jeffrey N.
Afiliação
  • Osman AA; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Monroe MM; Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.
  • Ortega Alves MV; Department of Internal Medicine, Tufts Medical Center, Boston, Massachusetts.
  • Patel AA; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Katsonis P; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
  • Fitzgerald AL; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Neskey DM; Department of Otolaryngology Head and Neck Surgery, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
  • Frederick MJ; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Woo SH; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Caulin C; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Hsu TK; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
  • McDonald TO; Department of Statistics, Rice University, Houston, Texas.
  • Kimmel M; Department of Statistics, Rice University, Houston, Texas.
  • Meyn RE; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Lichtarge O; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.
  • Myers JN; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas. jmyers@mdanderson.org.
Mol Cancer Ther ; 14(2): 608-19, 2015 Feb.
Article em En | MEDLINE | ID: mdl-25504633
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Proteínas Nucleares / Proteína Supressora de Tumor p53 / Cisplatino / Proteínas de Ciclo Celular / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Pontos de Checagem do Ciclo Celular / Neoplasias de Cabeça e Pescoço / Mutação Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Proteínas Nucleares / Proteína Supressora de Tumor p53 / Cisplatino / Proteínas de Ciclo Celular / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Pontos de Checagem do Ciclo Celular / Neoplasias de Cabeça e Pescoço / Mutação Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article