Closed-loop optimization of chromatography column sizing strategies in biopharmaceutical manufacture.

Allmendinger, Richard; Simaria, Ana S; Turner, Richard; Farid, Suzanne S

Allmendinger, Richard; Simaria, Ana S; Turner, Richard; Farid, Suzanne S.

Afiliação

Allmendinger R; The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London Torrington Place, London, WC1E 7JE, UK.
Simaria AS; The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London Torrington Place, London, WC1E 7JE, UK.
Turner R; MedImmune Limited, Milstein Building Granta Park, Cambridge, CB1 6GH, UK.
Farid SS; The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London Torrington Place, London, WC1E 7JE, UK.

J Chem Technol Biotechnol ; 89(10): 1481-1490, 2014 Oct.

Article em En | MEDLINE | ID: mdl-25506115

Palavras-chave

antibody purification technologies; biopharmaceutical manufacture; closed-loop optimization; downstream processing design; evolutionary computation; process economics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2014 Tipo de documento: Article