Overexpression of ankyrin repeat domain 1 enhances cardiomyocyte apoptosis by promoting p53 activation and mitochondrial dysfunction in rodents.

Shen, Liang; Chen, Ci; Wei, Xuan; Li, Xixian; Luo, Guangjin; Zhang, Jingwen; Bin, Jianping; Huang, Xiaobo; Cao, Shiping; Li, Guofeng; Liao, Yulin

Shen, Liang; Chen, Ci; Wei, Xuan; Li, Xixian; Luo, Guangjin; Zhang, Jingwen; Bin, Jianping; Huang, Xiaobo; Cao, Shiping; Li, Guofeng; Liao, Yulin.

Afiliação

Shen L; *State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Chen C; *State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Wei X; *State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Li X; *State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Luo G; *State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Zhang J; *State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Bin J; *State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Huang X; *State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Cao S; *State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Li G; Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Liao Y; *State Key Laboratory of Organ Failure Research, Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Clin Sci (Lond) ; 128(10): 665-78, 2015 May 01.

Article em En | MEDLINE | ID: mdl-25511237

Assuntos

Apoptose/fisiologia; Regulação da Expressão Gênica/fisiologia; Insuficiência Cardíaca/metabolismo; Doenças Mitocondriais/metabolismo; Proteínas Musculares/metabolismo; Miócitos Cardíacos/fisiologia; Proteínas Nucleares/metabolismo; Proteínas Repressoras/metabolismo; Proteína Supressora de Tumor p53/metabolismo; Análise de Variância; Animais; Pressão Sanguínea; Western Blotting; Primers do DNA/genética; Camundongos; Camundongos Endogâmicos C57BL; Microscopia de Fluorescência; Doenças Mitocondriais/etiologia; Miócitos Cardíacos/metabolismo; Ratos; Reação em Cadeia da Polimerase em Tempo Real; Proteína X Associada a bcl-2/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Proteínas Nucleares / Regulação da Expressão Gênica / Proteína Supressora de Tumor p53 / Apoptose / Doenças Mitocondriais / Miócitos Cardíacos / Insuficiência Cardíaca / Proteínas Musculares Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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