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The increased transglutaminase 2 expression levels during initial tumorigenesis predict increased risk of metastasis and decreased disease-free and cancer-specific survivals in renal cell carcinoma.
Erdem, Selcuk; Yegen, Gulcin; Telci, Dilek; Yildiz, Ibrahim; Tefik, Tzevat; Issever, Halim; Kilicaslan, Isin; Sanli, Oner.
Afiliação
  • Erdem S; Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Yegen G; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Telci D; Department of Genetics and Bioengineering, Yeditepe University, Istanbul, Turkey.
  • Yildiz I; Department of Medical Oncology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Tefik T; Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Issever H; Department of Biostatistics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Kilicaslan I; Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Sanli O; Department of Urology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. sanlio@istanbul.edu.tr.
World J Urol ; 33(10): 1553-60, 2015 Oct.
Article em En | MEDLINE | ID: mdl-25515319
ABSTRACT

PURPOSE:

The aim of this study was to investigate the role of transglutaminase 2(TG2) in renal cell carcinoma (RCC) by comparing the immunohistochemistry staining of primary and metastatic tumor tissues.

METHODS:

A total of 33 metastatic RCC(mRCC) and 33 non-metastatic RCC (nmRCC) patients who were matched as closely as possible based on gender, age, nuclear grade and pathologic T stage were retrospectively investigated. TG2 immunohistochemistry staining was performed on paraffin-embedded primary tumor tissues from both patient groups and on metastatic tissues from mRCC patients. The tissues were scored from 0 to 7 according to the TG2 staining. Furthermore, the patients were stratified into two groups using median primary tumor staining score as the cutoff value Group 1 (high risk, n = 41) and Group 2(low risk, n = 22). The clinical, histopathological and survival outcomes were compared between these risk groups using Chi-square test, t test, Mann-Whitney U test and Kaplan-Meier survival analyses.

RESULTS:

The median TG2 score for primary tumor was 5 for the entire study population. The median primary tumor TG2 score of the mRCC patients was significantly higher compared to the nmRCC patients (6 vs. 4, p < 0.001). The TG2 score between the primary and metastatic tissues of mRCC patients was not significantly different (6 vs. 7, p = 0.086). The percentage of metastatic patients was significantly higher in Group 1 compared to Group 2 (68.3 vs. 18.2 %, p < 0.001). Kaplan-Meier analyses showed that 5-year disease-free (34.9 vs. 92.9 %, p = 0.001) and cancer-specific (47.4 vs. 86.5 %, p = 0.04) survival rates were significantly lower in high-risk group.

CONCLUSIONS:

The increased expression of TG2 in primary tumor predicts metastasis in RCC patients and is also associated with a decrease in disease-free and cancer-specific survival outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Transglutaminases / Proteínas de Ligação ao GTP / Carcinogênese / Neoplasias Renais Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Renais / Transglutaminases / Proteínas de Ligação ao GTP / Carcinogênese / Neoplasias Renais Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article