Hepcidin is suppressed by erythropoiesis in hemoglobin E ß-thalassemia and ß-thalassemia trait.

Jones, Emma; Pasricha, Sant-Rayn; Allen, Angela; Evans, Patricia; Fisher, Chris A; Wray, Katherine; Premawardhena, Anuja; Bandara, Dyananda; Perera, Ashok; Webster, Craig; Sturges, Pamela; Olivieri, Nancy F; St Pierre, Timothy; Armitage, Andrew E; Porter, John B; Weatherall, David J; Drakesmith, Hal

Jones, Emma; Pasricha, Sant-Rayn; Allen, Angela; Evans, Patricia; Fisher, Chris A; Wray, Katherine; Premawardhena, Anuja; Bandara, Dyananda; Perera, Ashok; Webster, Craig; Sturges, Pamela; Olivieri, Nancy F; St Pierre, Timothy; Armitage, Andrew E; Porter, John B; Weatherall, David J; Drakesmith, Hal.

Afiliação

Jones E; Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;
Pasricha SR; Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;
Allen A; College of Medicine, Swansea University, Swansea, United Kingdom;
Evans P; University College of London Cancer Institute, Department of Haematology, University College London, United Kingdom;
Fisher CA; Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;
Wray K; Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;
Premawardhena A; University of Kelaniya, Colombo, Sri Lanka;
Bandara D; National Thalassaemia Centre, District Hospital, Kurunegala, Sri Lanka;
Perera A; National Thalassaemia Centre, District Hospital, Kurunegala, Sri Lanka;
Webster C; Department of Biochemistry and Immunology, Birmingham Heartlands Hospital, Birmingham, United Kingdom;
Sturges P; Department of Biochemistry and Immunology, Birmingham Heartlands Hospital, Birmingham, United Kingdom;
Olivieri NF; University Health Network, University of Toronto, ON, Canada; and.
St Pierre T; School of Physics, University of Western Australia, Crawley, Australia.
Armitage AE; Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;
Porter JB; University College of London Cancer Institute, Department of Haematology, University College London, United Kingdom;
Weatherall DJ; Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;
Drakesmith H; Medical Research Council, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom;

Blood ; 125(5): 873-80, 2015 Jan 29.

Article em En | MEDLINE | ID: mdl-25519750

Assuntos

Hemoglobina E/genética; Hepcidinas/genética; Sobrecarga de Ferro/genética; Globinas beta/genética; Talassemia beta/genética; Adolescente; Adulto; Portador Sadio; Estudos de Casos e Controles; Criança; Pré-Escolar; Eritropoese/genética; Feminino; Regulação da Expressão Gênica; Genótipo; Hemoglobina E/metabolismo; Hepcidinas/metabolismo; Humanos; Ferro/metabolismo; Sobrecarga de Ferro/etiologia; Sobrecarga de Ferro/metabolismo; Sobrecarga de Ferro/patologia; Modelos Lineares; Masculino; Pessoa de Meia-Idade; Mutação; Fenótipo; Índice de Gravidade de Doença; Sri Lanka; Reação Transfusional; Globinas beta/metabolismo; Talassemia beta/metabolismo; Talassemia beta/patologia; Talassemia beta/terapia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina E / Talassemia beta / Sobrecarga de Ferro / Globinas beta / Hepcidinas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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