Stabilization of morphine tolerance with long-term dosing: association with selective upregulation of mu-opioid receptor splice variant mRNAs.

Xu, Jin; Faskowitz, Andrew J; Rossi, Grace C; Xu, Mingming; Lu, Zhigang; Pan, Ying-Xian; Pasternak, Gavril W

Xu, Jin; Faskowitz, Andrew J; Rossi, Grace C; Xu, Mingming; Lu, Zhigang; Pan, Ying-Xian; Pasternak, Gavril W.

Afiliação

Xu J; Department of Neurology and the Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065; and.
Faskowitz AJ; Department of Neurology and the Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065; and.
Rossi GC; Department of Psychology, Long Island University, C. W. Post, Brookville, NY 11548.
Xu M; Department of Neurology and the Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065; and.
Lu Z; Department of Neurology and the Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065; and.
Pan YX; Department of Neurology and the Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065; and pany@mskcc.org pasterng@mskcc.org.
Pasternak GW; Department of Neurology and the Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065; and pany@mskcc.org pasterng@mskcc.org.

Proc Natl Acad Sci U S A ; 112(1): 279-84, 2015 Jan 06.

Article em En | MEDLINE | ID: mdl-25535370

Assuntos

Processamento Alternativo/genética; Morfina/farmacologia; Receptores Opioides mu/genética; Regulação para Cima/efeitos dos fármacos; Processamento Alternativo/efeitos dos fármacos; Animais; Encéfalo/efeitos dos fármacos; Encéfalo/fisiologia; Relação Dose-Resposta a Droga; Masculino; Camundongos; Morfina/administração & dosagem; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Receptores Opioides mu/metabolismo; Regulação para Cima/genética

Palavras-chave

MOR-1; analgesia; opiate receptor; opioid; splice variant

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Regulação para Cima / Processamento Alternativo / Receptores Opioides mu / Morfina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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