Antiretroviral treatment program retention among HIV-infected children in the Democratic Republic of Congo.
PLoS One
; 9(12): e113877, 2014.
Article
em En
| MEDLINE
| ID: mdl-25541707
ABSTRACT
BACKGROUND:
Retaining patients with HIV infection in care is still a major challenge in sub- Saharan Africa, particularly in the Democratic Republic of Congo (DRC) where the antiretroviral treatment (ART) coverage is low. Monitoring retention is an important tool for evaluating the quality of care. METHODS ANDFINDINGS:
A review of medical records of HIV-infected children was performed in three health facilities in the DRC the Amo-Congo Health center, the Monkole Clinic in Kinshasa, and the HEAL Africa Clinic in Goma. Medical records of 720 children were included. Kaplan Meier curves were constructed with the probability of retention at 6 months, 1 year, 2 years and 3 years. Retention rates were 88.2% (95% CI 85.1%-90.8%) at 6 months; 85% (95% CI 81.5%-87.6%) at one year; 79.4% (95%CI 75.5%-82.8%) at two years and 74.7% (95% CI 70.5%-78.5%) at 3 years. The retention varied across study sites 88.2%, 66.6% and 92.5% at 6 months; 84%, 59% and 90% at 12 months and 75.7%, 56.3% and 85.8% at 24 months respectively for Amo-Congo/Kasavubu, Monkole facility and HEAL Africa. After multivariable Cox regression four variables remained independently associated with attrition study site, CD4 cell count <350 cells/µL, children younger than 2 years and children whose caregivers were member of an independent church.CONCLUSIONS:
Attrition remains a challenge for pediatric HIV positive patients in ART programs in DRC. In addition, the low coverage of pediatric treatment exacerbates the situation of pediatric HIV/AIDS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Antirretrovirais
/
Adesão à Medicação
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
País/Região como assunto:
Africa
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article