Control of protein function by prolyl isomerization.
Biochim Biophys Acta
; 1850(10): 1973-82, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-25542300
ABSTRACT
BACKGROUND:
Prolyl cis/trans isomerizations have long been known as critical and rate-limiting steps in protein folding.RESULTS:
Now it is clear that they are also used as slow conformational switches and molecular timers in the regulation of protein activity. Here we describe several such proline switches and how they are regulated. CONCLUSIONS AND GENERALSIGNIFICANCE:
Prolyl isomerizations can function as attenuators and provide allosteric systems with a molecular memory. This article is part of a Special Issue entitled Proline-directed Foldases Cell Signaling Catalysts and Drug Targets.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prolina
/
Proteínas
/
Dobramento de Proteína
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article