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Development of a mouse-adapted live attenuated influenza virus that permits in vivo analysis of enhancements to the safety of live attenuated influenza virus vaccine.
Cox, Andrew; Baker, Steven F; Nogales, Aitor; Martínez-Sobrido, Luis; Dewhurst, Stephen.
Afiliação
  • Cox A; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
  • Baker SF; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
  • Nogales A; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
  • Martínez-Sobrido L; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA luis_martinez@urmc.rochester.edu stephen_dewhurst@urmc.rochester.edu.
  • Dewhurst S; Department of Microbiology and Immunology, University of Rochester, Rochester, New York, USA luis_martinez@urmc.rochester.edu stephen_dewhurst@urmc.rochester.edu.
J Virol ; 89(6): 3421-6, 2015 Mar.
Article em En | MEDLINE | ID: mdl-25552727
ABSTRACT
The live attenuated influenza virus vaccine (LAIV) is preferentially recommended for use in persons 2 through 49 years of age but has not been approved for children under 2 or asthmatics due to safety concerns. Therefore, increasing safety is desirable. Here we describe a murine LAIV with reduced pathogenicity that retains lethality at high doses and further demonstrate that we can enhance safety in vivo through mutations within NS1. This model may permit preliminary safety analysis of improved LAIVs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Vacinas contra Influenza / Vacinas Atenuadas / Modelos Animais de Doenças / Influenza Humana / Camundongos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Influenza A / Vacinas contra Influenza / Vacinas Atenuadas / Modelos Animais de Doenças / Influenza Humana / Camundongos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article