Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells.
Blood Cells Mol Dis
; 54(4): 329-35, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25554682
ABSTRACT
MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
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Regulação Neoplásica da Expressão Gênica
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Apoptose
Tipo de estudo:
Observational_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article