[Evaluation of six cases with hypothalamic hamartoma: the relationship between MRI findings and clinical features].
No To Hattatsu
; 46(6): 419-23, 2014 Nov.
Article
em Ja
| MEDLINE
| ID: mdl-25558584
ABSTRACT
OBJECTIVE:
We evaluated the relationship between MRI findings and clinical features in patients with hypothalamic hamartoma (HH).METHODS:
We retrospectively reviewed MRI and clinical data (mental retardation, precocious puberty, behavioral problems, and epilepsy) in six patients (3 males and 3 females, ages 12 to 26) with HH. Based on the MRI classification by Arita, HH was classified into two types parahypothalamic (P) and intrahypothalamic (I).RESULTS:
Only one patient was classified as having P-type HH and five were classified as having I-type HH. The patient with P-type HH (diameter 21 mm) showed precocious puberty and mild behavioral problems, but did not developed epilepsy. On the other hand, all patients with I-type HH (diameter 10-32 mm, median 17 mm) developed epilepsy and behavioral problems. Except for one patient, who had the smallest sized HH, I-type four patients developed mental retardation and precocious puberty. Among patients with I-type HH, the size of the tumor was inversely correlated with the age at epilepsy onset and with the degree of mental retardation (DQ/IQ).CONCLUSION:
Our data suggested that the MRI classification by Arita, when combined with tumor size, might be helpful in predicting the clinical manifestations in patients with HH.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Epilepsia
/
Hamartoma
/
Hipocampo
/
Doenças Hipotalâmicas
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
Ja
Ano de publicação:
2014
Tipo de documento:
Article