Tricin derivatives as anti-inflammatory and anti-allergic constituents from the aerial part of Zizania latifolia.
Biosci Biotechnol Biochem
; 79(5): 700-6, 2015.
Article
em En
| MEDLINE
| ID: mdl-25559019
ABSTRACT
Methanol extract of Zizania latifolia was partitioned with EtOAc, n-BuOH, and H2O. From the EtOAc layers, a new flavonolignan along with a known flavone and three known flavonolignans, tricin (1), salcolin A (2), salcolin B (3), and salcolin C (4), were isolated through repeated silica gel and ODS column chromatography. The chemical structure of the new flavonolignan was determined to be tricin-4'-O-[erythro-ß-guaiacyl-(7â³-O-methyl)-glyceryl] ether and was named salcolin D (5) based on physicochemical and spectroscopic data, including FT-NMR and ESI-MS. All compounds were isolated for the first time from this plant. Compounds 2-5, tricin derivatives, all exhibited higher anti-inflammatory and anti-allergy activities than tricin. In particular, salcolin D (5) was shown to have the strongest inhibitory activity against LPS-induced NO production in RAW 264.7 cells as well as ß-hexosaminidase release in IgE-sensitized RBL-2H3 cells. These results suggest that the presence of tricin derivatives conveys allergy and inflammation treatment ability to Z. latifolia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
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Anti-Inflamatórios não Esteroides
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Antialérgicos
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Poaceae
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article