Resveratrol inhibits high glucose induced collagen upregulation in cardiac fibroblasts through regulating TGF-ß1-Smad3 signaling pathway.

Liu, Junhui; Zhuo, Xiaozhen; Liu, Weimin; Wan, Zhaofei; Liang, Xiao; Gao, Shanshan; Yuan, Zuyi; Wu, Yue

Liu, Junhui; Zhuo, Xiaozhen; Liu, Weimin; Wan, Zhaofei; Liang, Xiao; Gao, Shanshan; Yuan, Zuyi; Wu, Yue.

Afiliação

Liu J; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, 277 West Yanta Road, Xi'an 710061, Shaanxi, China; Department of Clinical Laboratory, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, 277 West Yanta Road, Xi'an 71006
Zhuo X; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, 277 West Yanta Road, Xi'an 710061, Shaanxi, China.
Liu W; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, 277 West Yanta Road, Xi'an 710061, Shaanxi, China.
Wan Z; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, 277 West Yanta Road, Xi'an 710061, Shaanxi, China.
Liang X; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, 277 West Yanta Road, Xi'an 710061, Shaanxi, China.
Gao S; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, 277 West Yanta Road, Xi'an 710061, Shaanxi, China.
Yuan Z; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, 277 West Yanta Road, Xi'an 710061, Shaanxi, China. Electronic address: zuyiyuan@mail.xjtu.edu.cn.
Wu Y; Department of Cardiology, First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, 277 West Yanta Road, Xi'an 710061, Shaanxi, China. Electronic address: imyuewu@gmail.com.

Chem Biol Interact ; 227: 45-52, 2015 Feb 05.

Article em En | MEDLINE | ID: mdl-25559857

Assuntos

Colágeno/metabolismo; Glucose/farmacologia; Transdução de Sinais/efeitos dos fármacos; Estilbenos/farmacologia; Angiotensina II/farmacologia; Animais; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Diabetes Mellitus Experimental/induzido quimicamente; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Fibroblastos/citologia; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Miocárdio/citologia; Ratos; Ratos Wistar; Resveratrol; Proteína Smad3/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Regulação para Cima/efeitos dos fármacos

Palavras-chave

Angiotensin II (Ang II); Cardiac fibroblasts (CFs); Cardiac fibrosis; Collagens; Resveratrol (Res)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estilbenos / Transdução de Sinais / Colágeno / Glucose Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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