Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma.

Newman, Erika A; Lu, Fujia; Bashllari, Daniela; Wang, Li; Opipari, Anthony W; Castle, Valerie P

Newman, Erika A; Lu, Fujia; Bashllari, Daniela; Wang, Li; Opipari, Anthony W; Castle, Valerie P.

Afiliação

Newman EA; Department of Surgery, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan. eanewman@med.umich.edu.
Lu F; Department of Surgery, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan.
Bashllari D; Department of Surgery, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan.
Wang L; Department of Pediatrics, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan.
Opipari AW; Department of Obstetrics and Gynecology, C.S. Mott Children and Women's Hospital, The University of Michigan Medical School, Ann Arbor, Michigan.
Castle VP; Department of Pediatrics, C.S. Mott Children and Women's Hospital, Translational Oncology Program, The University of Michigan Medical School, Ann Arbor, Michigan.

Mol Cancer Res ; 13(3): 470-82, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25563294

Assuntos

Quebras de DNA de Cadeia Dupla; Reparo do DNA por Junção de Extremidades; Neuroblastoma/genética; Linhagem Celular Tumoral; Sobrevivência Celular; Quebras de DNA de Cadeia Dupla/efeitos dos fármacos; Reparo do DNA por Junção de Extremidades/efeitos dos fármacos; Enzimas Reparadoras do DNA/genética; Enzimas Reparadoras do DNA/metabolismo; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Inibidores Enzimáticos/farmacologia; Regulação Neoplásica da Expressão Gênica; Humanos; Neuroblastoma/tratamento farmacológico; Neuroblastoma/patologia; Poli(ADP-Ribose) Polimerase-1; Poli(ADP-Ribose) Polimerases/metabolismo; Prognóstico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quebras de DNA de Cadeia Dupla / Reparo do DNA por Junção de Extremidades / Neuroblastoma Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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