Adventitial CXCL1/G-CSF expression in response to acute aortic dissection triggers local neutrophil recruitment and activation leading to aortic rupture.

Anzai, Atsushi; Shimoda, Masayuki; Endo, Jin; Kohno, Takashi; Katsumata, Yoshinori; Matsuhashi, Tomohiro; Yamamoto, Tsunehisa; Ito, Kentaro; Yan, Xiaoxiang; Shirakawa, Kosuke; Shimizu-Hirota, Ryoko; Yamada, Yoshitake; Ueha, Satoshi; Shinmura, Ken; Okada, Yasunori; Fukuda, Keiichi; Sano, Motoaki

Anzai, Atsushi; Shimoda, Masayuki; Endo, Jin; Kohno, Takashi; Katsumata, Yoshinori; Matsuhashi, Tomohiro; Yamamoto, Tsunehisa; Ito, Kentaro; Yan, Xiaoxiang; Shirakawa, Kosuke; Shimizu-Hirota, Ryoko; Yamada, Yoshitake; Ueha, Satoshi; Shinmura, Ken; Okada, Yasunori; Fukuda, Keiichi; Sano, Motoaki.

Afiliação

Anzai A; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Shimoda M; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Endo J; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Kohno T; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Katsumata Y; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Matsuhashi T; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Yamamoto T; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Ito K; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Yan X; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Shirakawa K; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Shimizu-Hirota R; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Yamada Y; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Ueha S; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Shinmura K; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Okada Y; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Fukuda K; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)
Sano M; From the Division of Cardiology, Department of Medicine (A.A., J.E., T.K., Y.K., T.M., T.Y., K.I., X.Y., K.S. K.S., F.F., M.S.), Department of Pathology (M.S., Y.O.), Division of Endocrinology, Metabolism and Nephrology, Department of Medicine (R.S.-H.), and Department of Diagnostic Radiology (Y.Y.)

Circ Res ; 116(4): 612-23, 2015 Feb 13.

Article em En | MEDLINE | ID: mdl-25563839

Assuntos

Túnica Adventícia/metabolismo; Aorta Torácica/metabolismo; Aneurisma da Aorta Torácica/metabolismo; Dissecção Aórtica/metabolismo; Ruptura Aórtica/metabolismo; Quimiocina CXCL1/metabolismo; Fator Estimulador de Colônias de Granulócitos/metabolismo; Ativação de Neutrófilo; Infiltração de Neutrófilos; Neutrófilos/metabolismo; Doença Aguda; Túnica Adventícia/diagnóstico por imagem; Idoso; Aminopropionitrilo/análogos & derivados; Dissecção Aórtica/induzido quimicamente; Dissecção Aórtica/diagnóstico por imagem; Dissecção Aórtica/tratamento farmacológico; Angiotensina II; Animais; Anticorpos Monoclonais/farmacologia; Aorta Torácica/diagnóstico por imagem; Aneurisma da Aorta Torácica/induzido quimicamente; Aneurisma da Aorta Torácica/diagnóstico por imagem; Aneurisma da Aorta Torácica/tratamento farmacológico; Ruptura Aórtica/induzido quimicamente; Ruptura Aórtica/diagnóstico por imagem; Ruptura Aórtica/prevenção & controle; Aortografia; Quimiocina CXCL12/metabolismo; Quimiotaxia de Leucócito; Dilatação Patológica; Modelos Animais de Doenças; Feminino; Humanos; Mediadores da Inflamação/metabolismo; Interleucina-6/sangue; Interleucina-6/genética; Interleucina-6/metabolismo; Interleucina-8/sangue; Masculino; Camundongos Endogâmicos C57BL; Camundongos Knockout; Pessoa de Meia-Idade; Ativação de Neutrófilo/efeitos dos fármacos; Infiltração de Neutrófilos/efeitos dos fármacos; Neutrófilos/efeitos dos fármacos; Neutrófilos/transplante; Receptores de Interleucina-8B/antagonistas & inibidores; Receptores de Interleucina-8B/metabolismo; Transdução de Sinais; Fatores de Tempo

Palavras-chave

angiotensin II; aortic dissection; chemokines; inflammation; interleukin-6; neutrophils

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta Torácica / Ruptura Aórtica / Fator Estimulador de Colônias de Granulócitos / Aneurisma da Aorta Torácica / Ativação de Neutrófilo / Infiltração de Neutrófilos / Quimiocina CXCL1 / Túnica Adventícia / Dissecção Aórtica / Neutrófilos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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