[Insertion/deletion polymorphism of IL1A 3'-UTR associated with the susceptibility of prostate cancer ].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 45(6): 956-9, 2014 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-25571723
ABSTRACT
OBJECTIVE:
To identify the association between the insertion/deletion polymorphism of interleukin- 1A gene (IL1A) and the susceptibility of prostate cancer (PCA).METHODS:
We performed a case-control study enrolling 131 PCA patients and 229 healthy control subjects in a Chinese Han population. The TTCA insertion/ deletion polymorphism (rs3783553) in 3'-UTR of IL1A gene was genotyped by PCR-RFLP method.RESULTS:
The genotype distribution of rs3783553 in both groups met the requirements of Hardy-Weinberg equilibrium. Significantly reduced PCA risk was associated with D/I and I/I genotype compared to D/D genotype (P<0. 001, OR=O. 48, 95%CI 0.31-0.74), and allele I is associated with the reduced PCA risk (P=0. 001,OR=0. 56,95% CI 0. 40-0. 79).CONCLUSION:
TTCA insertion allele of rs3783553 contributes to the reduction of the susceptibility to prostate cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Predisposição Genética para Doença
/
Interleucina-1alfa
/
Mutação INDEL
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article