A special healing pattern in stable metaphyseal fractures.
Acta Orthop
; 86(2): 238-42, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25582035
ABSTRACT
BACKGROUND AND PURPOSE:
Metaphyseal fractures heal in a rapid fashion that is different from the bone shaft healing process. Animal studies have focused on diaphyseal fractures. We investigated the metaphyseal fracture-healing process in rabbits. ANIMALS ANDMETHODS:
60 rabbits (divided into 12 groups) underwent proximal tibial osteotomy, anatomical reduction, and fixation with screws. After surgery, the proximal tibiae were harvested at different time points for histology.RESULTS:
No obvious osteonecrosis or bone resorption were found 2 weeks after surgery. From day 5 to week 5, woven bone or new trabeculae formed. From week 2, remodeling into lamellar bone started and reached a peak at week 6. These 3 stages overlapped. Histomorphometry showed that the structure changed as a unimodal curve.INTERPRETATION:
The healing process of metaphyseal fractures appears to differ from the commonly studied healing process in diaphyseal fractures. It is rapid, and can be divided into 4 histological stages cellular activation and differentiation, formation of woven bone, transformation of woven bone into lamellar bone, and further remodeling.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteonecrose
/
Tíbia
/
Fraturas da Tíbia
/
Reabsorção Óssea
/
Consolidação da Fratura
/
Fixação Interna de Fraturas
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article