Reactivity of the [M(PS)2](+) building block (M = Re(III) and (99m)Tc(III); PS = phosphinothiolate) toward isopropylxanthate and pyridine-2-thiolate.
Inorg Chem
; 54(4): 1634-44, 2015 Feb 16.
Article
em En
| MEDLINE
| ID: mdl-25588027
ABSTRACT
The coordination properties of isopropylxanthate (i-Pr-Tiox) and pyridine-2-thiolate (PyS) toward the [M(PS)2](+) moiety (M = Re and (99m)Tc; PS = phosphinothiolate) were investigated. Synthesis and full characterization of [Re(PS2)2(i-Pr-Tiox)] (Re1), [Re(PSiso)2(i-Pr-Tiox)] (Re2), [Re(PS2)2(PyS)] (Re3), and [Re(PSiso)2(PyS)] (Re4), where PS2 = 2-(diphenylphosphino)ethanethiolate and PSiso = 2-(diisopropylphosphino)ethanethiolate, and the structural X-ray analysis of complex Re3 were carried out. (99m)Tc analogues of complexes Re2 ((99m)Tc2) and Re4 ((99m)Tc4) were obtained in high radiochemical yield following a simple one-pot procedure. The chemical identity of the radiolabeled compounds was confirmed by chromatographic comparison with the corresponding rhenium complexes and by dual radio/UV HPLC analysis combined with ESI(+)-MS of (99g/99m)Tc complexes prepared in carrier-added conditions. The two radiolabeled complexes were stable with regard to trans chelation with cysteine, glutathione, and ethylenediaminotetraacetic acid and in rat and human sera. This study highlights the substitution-inert metal-fragment behavior of the [M(PS)2](+) framework, which reacts with suitable bidentate coligands to form stable hexacoordinated asymmetrical complexes. This feature makes it a promising platform on which to develop a new class of Re/Tc complexes that are potentially useful in radiopharmaceutical applications.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Fosfinas
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Piridinas
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Rênio
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Compostos de Sulfidrila
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Tionas
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Tecnécio
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article