Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases.

Cleophas, Maartje C P; Crisan, Tania O; Lemmers, Heidi; Toenhake-Dijkstra, Helga; Fossati, Gianluca; Jansen, Tim L; Dinarello, Charles A; Netea, Mihai G; Joosten, Leo A B

Cleophas, Maartje C P; Crisan, Tania O; Lemmers, Heidi; Toenhake-Dijkstra, Helga; Fossati, Gianluca; Jansen, Tim L; Dinarello, Charles A; Netea, Mihai G; Joosten, Leo A B.

Afiliação

Cleophas MC; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Crisan TO; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Lemmers H; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Toenhake-Dijkstra H; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Fossati G; Department of Research and Development, Italfarmaco, Cinisello Balsamo, Italy.
Jansen TL; Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.
Dinarello CA; Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado, USA Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Netea MG; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Joosten LA; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Ann Rheum Dis ; 75(3): 593-600, 2016 Mar.

Article em En | MEDLINE | ID: mdl-25589513

Assuntos

Antioxidantes/farmacologia; Artrite Gotosa; Butiratos/farmacologia; Citocinas/efeitos dos fármacos; Inibidores Enzimáticos/farmacologia; Inibidores de Histona Desacetilases/farmacologia; Ácido Palmítico/farmacologia; RNA Mensageiro/efeitos dos fármacos; Ácido Úrico/farmacologia; Adulto; Carbamatos/farmacologia; Cristalização; Citocinas/genética; Citocinas/metabolismo; Ensaio de Imunoadsorção Enzimática; Feminino; Histona Desacetilases; Humanos; Ácidos Hidroxâmicos/farmacologia; Indóis/farmacologia; Interleucina-1beta/efeitos dos fármacos; Interleucina-1beta/genética; Interleucina-1beta/metabolismo; Interleucina-6/metabolismo; Interleucina-8/efeitos dos fármacos; Interleucina-8/metabolismo; Leucócitos Mononucleares; Masculino; Pessoa de Meia-Idade; Panobinostat; RNA Mensageiro/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa

Palavras-chave

Arthritis; Cytokines; Gout; Inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Úrico / Butiratos / RNA Mensageiro / Artrite Gotosa / Citocinas / Ácido Palmítico / Inibidores Enzimáticos / Inibidores de Histona Desacetilases / Antioxidantes Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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