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An 18-year-old woman with a 34-cm metaplastic breast carcinoma.
Gomes, António; Santos, Vanessa; Dias, Gonçalo; Manso, Rita Theias; Gonçalves, Lucília; Coiteiro, Margarida; Gaspar, Helena; Nazaré, Antónia.
Afiliação
  • Gomes A; B Surgery Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal apspgomes@gmail.com.
  • Santos V; Gynecology/Senology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.
  • Dias G; Gynecology/Senology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.
  • Manso RT; Pathology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.
  • Gonçalves L; Pathology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.
  • Coiteiro M; Gynecology/Senology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.
  • Gaspar H; Gynecology/Senology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.
  • Nazaré A; Gynecology/Senology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.
J Surg Case Rep ; 2015(1)2015 Jan 14.
Article em En | MEDLINE | ID: mdl-25589538
ABSTRACT
Metaplastic breast carcinomas (MBCs) are rare malignancies usually with poor prognosis. We report a case of an 18-year-old African female patient who presented with a 34-cm tumor on the right breast. Biopsy showed an extensively necrotic MBC negative for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (triple negative). A modified right radical mastectomy was performed, followed by adjuvant chemotherapy. Histology confirmed a widely necrotic undifferentiated malignant tumor, with strong and diffuse expression of vimentin and B-cell lymphoma 2, focal high-molecular-weight keratins and focal CD34 expression; Ki67 was >90%. There was no skin, deep margin or lymph node involvement. Six months after surgery, the patient showed a 9 × 7 cm nodule adjacent to the suture and adherent to the anterior chest wall. The tumor was considered unresectable and the patient evolved with rapid systemic deterioration. The patient had a progression-free survival of 6 months and overall survival of 9 months.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2015 Tipo de documento: Article