ß-Spectrin regulates the hippo signaling pathway and modulates the basal actin network.
J Biol Chem
; 290(10): 6397-407, 2015 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-25589787
ABSTRACT
Emerging evidence suggests functional regulation of the Hippo pathway by the actin cytoskeleton, although the detailed molecular mechanism remains incomplete. In a genetic screen, we identified a requirement for ß-Spectrin in the posterior follicle cells for the oocyte repolarization process during Drosophila mid-oogenesis. ß-spectrin mutations lead to loss of Hippo signaling activity in the follicle cells. A similar reduction of Hippo signaling activity was observed after ß-Spectrin knockdown in mammalian cells. We further demonstrated that ß-spectrin mutations disrupt the basal actin network in follicle cells. The abnormal stress fiber-like actin structure on the basal side of follicle cells provides a likely link between the ß-spectrin mutations and the loss of the Hippo signaling activity phenotype.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oogênese
/
Espectrina
/
Proteínas Serina-Treonina Quinases
/
Proteínas de Drosophila
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Folículo Ovariano
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article