SnapShot: Fanconi anemia and associated proteins.
Cell
; 160(1-2): 354-354.e1, 2015 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-25594185
ABSTRACT
Fanconi anemia is a genetic disorder resulting from biallelic mutations in one of the 17 FANC genes. It is characterized by congenital abnormalities, bone marrow failure, and cancer predisposition. The underlying cause is genomic instability resulting from the deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly referred to as the Fanconi anemia-BRCA pathway. This SnapShot presents the key factors involved.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reparo do DNA
/
Proteínas de Grupos de Complementação da Anemia de Fanconi
/
Anemia de Fanconi
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article