Midazolam inhibits the formation of amyloid fibrils and GM1 ganglioside-rich microdomains in presynaptic membranes through the gamma-aminobutyric acid A receptor.

Yamamoto, Naoki; Arima, Hajime; Sugiura, Takeshi; Hirate, Hiroyuki; Kusama, Nobuyoshi; Suzuki, Kenji; Sobue, Kazuya

Yamamoto, Naoki; Arima, Hajime; Sugiura, Takeshi; Hirate, Hiroyuki; Kusama, Nobuyoshi; Suzuki, Kenji; Sobue, Kazuya.

Afiliação

Yamamoto N; Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Ishikawa, Japan; Laboratory of Neurochemistry, Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan. Electronic address: na-yamam@hokuriku-u.ac.jp.
Arima H; Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Aichi, Japan.
Sugiura T; Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Aichi, Japan.
Hirate H; Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Aichi, Japan.
Kusama N; Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Aichi, Japan.
Suzuki K; Laboratory of Molecular Medicinal Science, Department of Pharmacy, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Shiga, Japan.
Sobue K; Department of Anesthesiology and Medical Crisis Management, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Aichi, Japan.

Biochem Biophys Res Commun ; 457(4): 547-53, 2015 Feb 20.

Article em En | MEDLINE | ID: mdl-25600806

Assuntos

Amiloide/metabolismo; Anestésicos Intravenosos/farmacologia; Gangliosídeo G(M1)/metabolismo; Midazolam/farmacologia; Substâncias Protetoras/farmacologia; Receptores de GABA/metabolismo; Doença de Alzheimer/induzido quimicamente; Doença de Alzheimer/metabolismo; Animais; Células Cultivadas; Masculino; Camundongos; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Sinaptossomos/efeitos dos fármacos; Sinaptossomos/metabolismo

Palavras-chave

Alzheimer's disease; Amyloid ß-protein; GM1 ganglioside; Midazolam

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Midazolam / Receptores de GABA / Anestésicos Intravenosos / Substâncias Protetoras / Gangliosídeo G(M1) / Amiloide Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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