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Increase in the oxidised low-density lipoprotein level by smoking and the possible inhibitory effect of statin therapy in patients with cardiovascular disease: a retrospective study.
Ogawa, Kazuo; Tanaka, Toshikazu; Nagoshi, Tomohisa; Sekiyama, Hiroshi; Arase, Satoshi; Minai, Kosuke; Ogawa, Takayuki; Yoshimura, Michihiro.
Afiliação
  • Ogawa K; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  • Tanaka T; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  • Nagoshi T; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  • Sekiyama H; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  • Arase S; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  • Minai K; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  • Ogawa T; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
  • Yoshimura M; Division of Cardiology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
BMJ Open ; 5(1): e005455, 2015 Jan 21.
Article em En | MEDLINE | ID: mdl-25609666
OBJECTIVES: Malondialdehyde-modified low-density lipoprotein (MDA-LDL) level is a marker of oxidative stress and is linked to progression of arteriosclerosis; however, the clinical factors affecting the oxidised LDL level have not been elucidated. We investigate various factors to identify correlation with MDA-LDL level in high-risk patients requiring catheter intervention. SETTING: Secondary care (cardiology), single-centre study. PARTICIPANTS: 600 patients who were admitted to our hospital and underwent cardiac catheterisation. PRIMARY AND SECONDARY OUTCOME MEASURES: Blood samples were obtained to measure lipid profiles and MDA-LDL level. RESULTS: With regard to smoking status, MDA-LDL level was significantly higher in ex-smokers/current smokers compared with non-smokers. Of note, there was no improvement of MDA-LDL level even in patients who had quit smoking. Multiple regression analysis showed that MDA-LDL level was positively correlated with LDL-cholesterol (LDL-C) level, Brinkman index and male gender. The correlation between smoking status and either MDA-LDL or LDL-C level was investigated in two groups: namely, patients with and patients without statin treatment. In the non-statin group, MDA-LDL level and MDA-LDL/LDL-C ratio were significantly higher in ex-smokers/current smokers compared with non-smokers, while no significant correlation was observed between smoking status and LDL-C level. In contrast, in the statin group, there were no significant correlations between smoking status and any of the cholesterol parameters. CONCLUSIONS: We found that MDA-LDL level was affected by multiple factors, such as smoking status, LDL-C level and male gender. The present findings give additional evidence that smoking should be prohibited from a MDA-LDL standpoint. Furthermore, statin therapy might have a beneficial effect on the reduction of MDA-LDL level.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Fumar / Inibidores de Hidroximetilglutaril-CoA Redutases / Lipoproteínas LDL Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Fumar / Inibidores de Hidroximetilglutaril-CoA Redutases / Lipoproteínas LDL Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2015 Tipo de documento: Article