The susceptibility of primate lentiviruses to nucleosides and Vpx during infection of dendritic cells is regulated by CA.
J Virol
; 89(7): 4030-4, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25609804
ABSTRACT
The block toward human immunodeficiency virus type 1 (HIV-1) infection of dendritic cells (DCs) can be relieved by Vpx (viral protein X), which degrades sterile alpha motif-hydroxylase domain 1 (SAMHD1) or by exogenously added deoxynucleosides (dNs), lending support to the hypothesis that SAMHD1 acts by limiting deoxynucleoside triphosphates (dNTPs). This notion has, however, been questioned. We show that while dNs and Vpx increase the infectivity of HIV-1, only the latter restores the infectivity of a simian immunodeficiency virus of macaques variant, SIVMACΔVpx virus. This distinct behavior seems to map to CA, suggesting that species-specific CA interactors modulate infection of DCs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Dendríticas
/
HIV-1
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Vírus da Imunodeficiência Símia
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Proteínas do Capsídeo
/
Proteínas Virais Reguladoras e Acessórias
/
Interações Hospedeiro-Patógeno
/
Nucleosídeos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article