Phosphorylation of spleen tyrosine kinase at tyrosine 348 (pSyk³48) may be a marker of advanced phase of Chronic Myeloid Leukemia (CML).
Leuk Res
; 39(3): 329-34, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25612940
ABSTRACT
We investigated Syk as a potential marker of CML progression. We observed a significant over-expression of Syk mRNA and constitutive phosphorylation of Syk Y348 in blast cells from six AP or BP-CML, but not in 15 CML in chronic phase. We could follow in vivo the recurrence of pSyk(348) throughout blast cell escape, despite observing storage of dasatinib in blast cells. A combination of dasatinib and R406 did not improve therapeutic efficacy in vitro. Our results strongly suggest that Syk activation could be a relevant biomarker of disease progression and dasatinib resistance but is probably not a molecular target.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Crise Blástica
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Peptídeos e Proteínas de Sinalização Intracelular
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged80
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article