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Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
Roecker, Anthony J; Mercer, Swati P; Bergman, Jeffrey M; Gilbert, Kevin F; Kuduk, Scott D; Harrell, C Meacham; Garson, Susan L; Fox, Steven V; Gotter, Anthony L; Tannenbaum, Pamela L; Prueksaritanont, Thomayant; Cabalu, Tamara D; Cui, Donghui; Lemaire, Wei; Winrow, Christopher J; Renger, John J; Coleman, Paul J.
Afiliação
  • Roecker AJ; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States. Electronic address: anthony_roecker@merck.com.
  • Mercer SP; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Bergman JM; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Gilbert KF; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Kuduk SD; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Harrell CM; Department of Neuroscience, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Garson SL; Department of Neuroscience, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Fox SV; Department of Neuroscience, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Gotter AL; Department of Neuroscience, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Tannenbaum PL; Department of Neuroscience, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Prueksaritanont T; Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Cabalu TD; Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Cui D; Department of Drug Metabolism, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Lemaire W; Department of In Vitro Pharmacology, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Winrow CJ; Department of Neuroscience, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Renger JJ; Department of Neuroscience, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Coleman PJ; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, United States.
Bioorg Med Chem Lett ; 25(21): 4992-4999, 2015 Nov 01.
Article em En | MEDLINE | ID: mdl-25613676
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Quinazolinas / Descoberta de Drogas / Receptores de Orexina / Antagonistas dos Receptores de Orexina / Distúrbios do Início e da Manutenção do Sono Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Quinazolinas / Descoberta de Drogas / Receptores de Orexina / Antagonistas dos Receptores de Orexina / Distúrbios do Início e da Manutenção do Sono Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article