Efficacy of short-term prednisolone treatment in patients with chronic eosinophilic pneumonia.
Eur Respir J
; 45(6): 1624-31, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25614171
ABSTRACT
In patients with chronic eosinophilic pneumonia (CEP), dramatic improvements are seen in response to corticosteroid therapy; however, relapse is common after treatment has ceased. The optimal duration of corticosteroid therapy remains unclear. In a randomised, open-label, parallel group study, eligible patients with CEP received oral prednisolone for either 3â
months (3-month group) or 6â
months (6-month group), followed by 2â
years observation. All patients were treated with an initial dose of prednisolone of 0.5â
mg·kg(-1)·day(-1), which was then tapered and discontinued at either 3 or 6â
months. The primary end-point was relapse during the follow-up period. In the final analysis, there were 23 patients in the 3-month group and 21 patients in the 6-month group. All patients showed a good response to prednisolone treatment. There were 12 (52.1%) relapses in the 3-month group and 13 (61.9%) relapses in the 6-month group. No significant difference was found in the cumulative rate of relapse (p=0.56). All relapse cases showed improvement upon resumption of prednisolone treatment. No difference was observed in the rate of relapse between the 3- and 6-month prednisolone treatment groups for patients with CEP.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eosinofilia Pulmonar
/
Prednisolona
/
Glucocorticoides
/
Pulmão
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article