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Amino acids substitutions in the PB2 protein of H7N9 influenza A viruses are important for virulence in mammalian hosts.
Yamayoshi, Seiya; Fukuyama, Satoshi; Yamada, Shinya; Zhao, Dongming; Murakami, Shin; Uraki, Ryuta; Watanabe, Tokiko; Tomita, Yuriko; Neumann, Gabriele; Kawaoka, Yoshihiro.
Afiliação
  • Yamayoshi S; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Fukuyama S; 1] Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan [2] ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan.
  • Yamada S; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Zhao D; 1] Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan [2] ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan.
  • Murakami S; Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan.
  • Uraki R; Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
  • Watanabe T; 1] Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan [2] ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan.
  • Tomita Y; 1] Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan [2] ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan.
  • Neumann G; Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 575 Science Drive, Madison, WI, USA.
  • Kawaoka Y; 1] Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan [2] ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama, Japan [3] Department of Special Pathogens, International Research Cent
Sci Rep ; 5: 8039, 2015 Jan 27.
Article em En | MEDLINE | ID: mdl-25623817
We tested the biological significance of two amino acid mutations in the PB2 protein (glutamic acid to lysine at position 627 and aspartic acid to asparagine at position 701) of A(H7N9) viruses for mammalian adaptation. Mutants were assessed for their viral polymerase activities, growth kinetics in mammalian and avian cells, and pathogenicity in mice. We found that lysine at position 627 and asparagine at position 701 in PB2 are essential for mammalian adaptation of A(H7N9) viruses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Virulência / Subtipo H7N9 do Vírus da Influenza A Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Virulência / Subtipo H7N9 do Vírus da Influenza A Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article