Enantioselective synthesis of 4-substituted tetrahydroisoquinolines via palladium-catalyzed intramolecular Friedel-Crafts type allylic alkylation of phenols.
Org Biomol Chem
; 13(10): 3086-92, 2015 Mar 14.
Article
em En
| MEDLINE
| ID: mdl-25625805
ABSTRACT
Palladium-catalyzed asymmetric intramolecular Friedel-Crafts type allylic alkylation reaction of phenols was developed under mild conditions. In the presence of Pd2(dba)3 with (1R,2R)-DACH-phenyl Trost ligand (L2) in toluene at 50 °C, the reaction provides various C4 substituted tetrahydroisoquinolines with moderate to excellent yields, regioselectivity and enantioselectivity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paládio
/
Fenóis
/
Tetra-Hidroisoquinolinas
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article