Synthesis and alpha 2-adrenoceptor antagonist activity of some disulfonamidobenzoquinolizines.
J Med Chem
; 32(1): 179-82, 1989 Jan.
Article
em En
| MEDLINE
| ID: mdl-2562854
ABSTRACT
A series of disulfonamidobenzo[a]quinolizines were synthesized and evaluated for their alpha 2- and alpha 1-adrenoceptor antagonist activity on the rat vas deferens and anococcygeus muscle, respectively. N-((2 beta,11b alpha)-1,3,4,6,7,11b-Hexahydro-2H-benzo[a]quinolizin-2-yl)-N- [2-[(methylsulfonyl)amino]ethyl]methanesulfonamide (4) and its N-[2-[(methylsulfonyl)amino]ethyl]ethanesulfonamide (22), N-[2-[(ethylsulfonyl)amino]ethyl]ethanesulfonamide (27), and N-[2-[(methylsulfonyl)amino]ethyl]-4-methylbenzenesulfonamide (30) analogues showed 400-fold or greater selectivity in favor of alpha 2- over alpha 1-adrenoceptor blockade.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinolizinas
/
Sulfonamidas
/
Antagonistas Adrenérgicos alfa
Limite:
Animals
Idioma:
En
Ano de publicação:
1989
Tipo de documento:
Article