Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology.
J Physiol
; 593(12): 2627-34, 2015 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-25640301
ABSTRACT
Unnatural amino acid incorporation into ion channels has proven to be a valuable approach to interrogate detailed hypotheses arising from atomic resolution structures. In this short review, we provide a brief overview of some of the basic principles and methods for incorporation of unnatural amino acids into proteins. We also review insights into the function and pharmacology of voltage-gated ion channels that have emerged from unnatural amino acid mutagenesis approaches.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais Iônicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article