Prognostic value of lymph node density in high-grade salivary gland cancers.
J Surg Oncol
; 111(6): 784-9, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25640975
ABSTRACT
BACKGROUND:
To investigate the role of lymph node density (LND) as an independent prognostic factor in high-grade salivary gland cancers.METHODS:
All 87 patients with high-grade salivary gland cancers underwent curative surgery combined with neck dissection and most of them received postoperative radiotherapy or chemoradiotherapy. LND was calculated as the ratio of positive lymph nodes to total lymph nodes harvested. Clinicopathologic variables associated with cancer-specific survival (CSS) and overall survival (OS) were identified by univariate and multivariate analyses using the Cox-proportional hazards model.RESULTS:
Salivary duct carcinoma was the most common tumor (54%), followed by carcinoma ex pleomorphic adenoma (22%), and others. The 5-year CSS and OS were 50.9% and 49.6%, respectively, during a median follow-up of 61 months. In univariate analysis, tumor site, pathologic nodal stage, overall tumor-node-metastasis (TNM) stage, primary tumor size > 3 cm, lymphovascular invasion, perineural invasion, extranodal extension, number of metastatic lymph nodes, and LND > 4.0 were significant prognostic factors for CSS and OS (P < 0.05 each). Tumor site, perineural invasion, and LND were independent prognostic factors for both CSS and OS in multivariate analysis (P < 0.01).CONCLUSION:
Our findings support the prognostic value of LND for high-grade salivary gland cancers.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esvaziamento Cervical
/
Neoplasias das Glândulas Salivares
/
Linfonodos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article