A correlation study of telomere length in peripheral blood leukocytes and kidney function with age.
Mol Med Rep
; 11(6): 4359-64, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25646618
ABSTRACT
The current study aimed to investigate the association between telomere length in peripheral blood leukocytes and kidney function in various age groups of a healthy population. A total of 139 healthy individuals were divided into five groups according to their age 3544, 4554, 5564, 6574 and >75 years old. Peripheral blood leukocytes were obtained and the telomere restriction fragment (TRF) length was assayed using a digoxigeninlabeled hybridization probe in Southern blot assays. Laboratory assays of kidney function were also performed. A correlation was observed between TRF length and age (r=0.314, P<0.001), with the telomere length of the individuals >75 years group being significantly shorter than the telomere length of the 3544, 4554 and 5564 years age groups (P<0.05). By contrast, the TRF length for males versus females did not differ for any of the age groups, while a correlation was observed between TRF length and serum levels of cystatin C (r=0.195, P<0.05). There was also a correlation between TRF length and glomerular filtration rate (r=0.184, P<0.05). The current study demonstrated that in this cohort, leukocyte telomere length reduced with age and was correlated with serum levels of cystatin C and glomerular filtration rate. Therefore, TRF length is associated with kidney function and may serve as a marker of aging.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Telômero
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Rim
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Leucócitos
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article