New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells.

Deng, Gai-Gai; Wei, Wei; Yang, Xiu-Wei; Zhang, You-Bo; Xu, Wei; Gong, Ning-Bo; Lü, Yang; Wang, Feng-Feng

Deng, Gai-Gai; Wei, Wei; Yang, Xiu-Wei; Zhang, You-Bo; Xu, Wei; Gong, Ning-Bo; Lü, Yang; Wang, Feng-Feng.

Afiliação

Deng GG; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, PR China. Electronic address: 378525114@qq.com.
Wei W; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, PR China.
Yang XW; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, PR China. Electronic address: xwyang@bjmu.edu.cn.
Zhang YB; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, PR China.
Xu W; State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, PR China.
Gong NB; Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PR China.
Lü Y; Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PR China.
Wang FF; Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PR China.

Fitoterapia ; 101: 194-200, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25647326

Assuntos

Angelica/química; Cumarínicos/química; Macrófagos/efeitos dos fármacos; Óxido Nítrico/metabolismo; Animais; Linhagem Celular; Cumarínicos/isolamento & purificação; Lipopolissacarídeos; Camundongos; Estrutura Molecular; Óxido Nítrico Sintase Tipo II/metabolismo; Raízes de Plantas/química; Relação Estrutura-Atividade

Palavras-chave

(+)-Decursinol (PubChem CID: 442127); (±)-Dahuribiscoumarin; (−)-Hydroxydecursinol; Angelica dahurica var. formosana cv. Chuanbaizhi; Coumarins; Imperatorin (PubChem CID: 10212); Inducible nitric oxide synthase; Isoimperatorin (PubChem CID: 68081); Nitric oxide; Phellopterin (PubChem CID: 98608)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cumarínicos / Angelica / Macrófagos / Óxido Nítrico Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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