Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra.

CriÈan, Tania O; Cleophas, Maartje C P; Oosting, Marije; Lemmers, Heidi; Toenhake-Dijkstra, Helga; Netea, Mihai G; Jansen, Tim L; Joosten, Leo A B

CriÈan, Tania O; Cleophas, Maartje C P; Oosting, Marije; Lemmers, Heidi; Toenhake-Dijkstra, Helga; Netea, Mihai G; Jansen, Tim L; Joosten, Leo A B.

Afiliação

CriÈan TO; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Science (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Na
Cleophas MC; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Science (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.
Oosting M; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Science (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.
Lemmers H; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Science (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.
Toenhake-Dijkstra H; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Science (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.
Netea MG; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Science (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.
Jansen TL; Department of Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands Department of Rheumatology, VieCuri Medical Centre, Venlo, The Netherlands.
Joosten LA; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands Radboud Institute of Molecular Life Science (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.

Ann Rheum Dis ; 75(4): 755-62, 2016 Apr.

Article em En | MEDLINE | ID: mdl-25649144

Assuntos

Citocinas/imunologia; Epigênese Genética/imunologia; Gota/imunologia; Leucócitos Mononucleares/imunologia; RNA Mensageiro/metabolismo; Receptor 2 Toll-Like/imunologia; Receptor 4 Toll-Like/imunologia; Ácido Úrico/imunologia; Adulto; Idoso; Idoso de 80 Anos ou mais; Antioxidantes/farmacologia; Estudos de Casos e Controles; Citocinas/efeitos dos fármacos; Citocinas/genética; Ensaio de Imunoadsorção Enzimática; Epigênese Genética/genética; Gota/genética; Código das Histonas; Histonas/metabolismo; Humanos; Inflamação; Proteína Antagonista do Receptor de Interleucina 1/efeitos dos fármacos; Proteína Antagonista do Receptor de Interleucina 1/genética; Proteína Antagonista do Receptor de Interleucina 1/imunologia; Interleucina-10/genética; Interleucina-10/imunologia; Interleucina-1beta/efeitos dos fármacos; Interleucina-1beta/genética; Interleucina-1beta/imunologia; Interleucina-6/genética; Interleucina-6/imunologia; Leucócitos Mononucleares/efeitos dos fármacos; Metilação; Pessoa de Meia-Idade; Fator de Necrose Tumoral alfa/efeitos dos fármacos; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/imunologia; Ácido Úrico/farmacologia

Palavras-chave

Cytokines; Gout; Inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Úrico / RNA Mensageiro / Leucócitos Mononucleares / Citocinas / Epigênese Genética / Receptor 2 Toll-Like / Receptor 4 Toll-Like / Gota Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Aged80 Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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