Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo.

Ma, Jiangtao; Duffy, Margaret R; Deng, Lin; Dakin, Rachel S; Uil, Taco; Custers, Jerome; Kelly, Sharon M; McVey, John H; Nicklin, Stuart A; Baker, Andrew H

Ma, Jiangtao; Duffy, Margaret R; Deng, Lin; Dakin, Rachel S; Uil, Taco; Custers, Jerome; Kelly, Sharon M; McVey, John H; Nicklin, Stuart A; Baker, Andrew H.

Afiliação

Ma J; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Duffy MR; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Deng L; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Dakin RS; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Uil T; Crucell Holland BV, Leiden, The Netherlands.
Custers J; Crucell Holland BV, Leiden, The Netherlands.
Kelly SM; Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
McVey JH; University of Surrey, Guildford, Surrey, United Kingdom.
Nicklin SA; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Baker AH; Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.

PLoS Pathog ; 11(2): e1004673, 2015 Feb.

Article em En | MEDLINE | ID: mdl-25658827

Assuntos

Adenovírus Humanos/imunologia; Anticorpos Antivirais/imunologia; Proteínas do Capsídeo/genética; Proteínas do Capsídeo/imunologia; Fator X/imunologia; Infecções por Adenovirus Humanos/imunologia; Infecções por Adenovirus Humanos/prevenção & controle; Adenovírus Humanos/genética; Animais; Anticorpos Neutralizantes/imunologia; Antígenos Virais/genética; Antígenos Virais/imunologia; Linhagem Celular Tumoral; Variação Genética/genética; Vetores Genéticos/genética; Células HEK293; Células HeLa; Humanos; Imunoglobulina M/sangue; Imunoglobulina M/imunologia; Camundongos; Camundongos Endogâmicos C57BL; Ressonância de Plasmônio de Superfície; Transdução Genética; Ligação Viral

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator X / Adenovírus Humanos / Proteínas do Capsídeo / Anticorpos Antivirais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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