Soluble epoxide hydrolase inhibition provides multi-target therapeutic effects in rats after spinal cord injury.

Chen, Xiaojing; Chen, Xiaoqi; Huang, Xiaojiang; Qin, Chuan; Fang, Yongkang; Liu, Yang; Zhang, Guibing; Pan, Dengji; Wang, Wei; Xie, Minjie

Chen, Xiaojing; Chen, Xiaoqi; Huang, Xiaojiang; Qin, Chuan; Fang, Yongkang; Liu, Yang; Zhang, Guibing; Pan, Dengji; Wang, Wei; Xie, Minjie.

Afiliação

Chen X; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Chen X; Department of Neurology, Nanyang City Center Hospital, Nanyang, 473000, People's Republic of China.
Huang X; Department of Neurology, Xinhua Hospital of Hubei Province, Wuhan, 430015, People's Republic of China.
Qin C; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Fang Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Liu Y; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Zhang G; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Pan D; Department of neurology, Xiangyang hospital affiliated to Hubei University of Medicine, Xiangyang, People's Republic of China.
Wang W; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
Xie M; Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Mol Neurobiol ; 53(3): 1565-1578, 2016 Apr.

Article em En | MEDLINE | ID: mdl-25663200

Assuntos

Epóxido Hidrolases/antagonistas & inibidores; Proteínas do Tecido Nervoso/antagonistas & inibidores; Traumatismos da Medula Espinal/tratamento farmacológico; Adamantano/análogos & derivados; Animais; Apoptose/efeitos dos fármacos; Ensaios de Seleção de Medicamentos Antitumorais; Comportamento Exploratório/efeitos dos fármacos; Proteína GAP-43/biossíntese; Proteína GAP-43/genética; Interleucina-1beta/biossíntese; Interleucina-1beta/genética; Ácidos Láuricos; Masculino; Microglia/efeitos dos fármacos; Neovascularização Fisiológica/efeitos dos fármacos; Infiltração de Neutrófilos/efeitos dos fármacos; Distribuição Aleatória; Ratos; Ratos Sprague-Dawley; Medula Espinal/irrigação sanguínea; Medula Espinal/enzimologia; Traumatismos da Medula Espinal/enzimologia

Palavras-chave

Glial scar; Inflammation; Myelin loss; Neuronal apoptosis; Spinal cord injury; sEH

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Epóxido Hidrolases / Proteínas do Tecido Nervoso Limite: Animals Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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