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Systemic exposure to and disposition of catechols derived from Salvia miltiorrhiza roots (Danshen) after intravenous dosing DanHong injection in human subjects, rats, and dogs.
Li, Meijuan; Wang, Fengqing; Huang, Yühong; Du, Feifei; Zhong, Chenchun; Olaleye, Olajide E; Jia, Weiwei; Li, Yanfen; Xu, Fang; Dong, Jiajia; Li, Jian; Lim, Justin B R; Zhao, Buchang; Jia, Lifu; Li, Li; Li, Chuan.
Afiliação
  • Li M; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Wang F; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Huang Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Du F; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Zhong C; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Olaleye OE; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Jia W; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Li Y; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Xu F; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Dong J; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Li J; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Lim JB; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Zhao B; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Jia L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Li L; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
  • Li C; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China (M.L., F.W., F.D., C.Z., O.E.O., W.J., F.X., J.D., J.L., J.B.R.L., L.L., C.L.); University of Chinese Academy of Sciences, Shanghai, China (M.L., L.L., C.L.); Second Affiliated Hospital, Tianjin University of Traditio
Drug Metab Dispos ; 43(5): 679-90, 2015 May.
Article em En | MEDLINE | ID: mdl-25670806
ABSTRACT
DanHong injection is a Danshen (Salvia miltiorrhiza roots)-based injectable solution for treatment of coronary artery disease and ischemic stroke. Danshen catechols are believed to be responsible for the injection's therapeutic effects. This study aimed to characterize systemic exposure to and elimination of Danshen catechols in human subjects, rats, and dogs receiving intravenous DanHong injection. A total of 28 catechols were detected, with content levels of 0.002-7.066 mM in the injection, and the major compounds included tanshinol, protocatechuic aldehyde, salvianolic acid B, rosmarinic acid, salvianolic acids A and D, and lithospermic acid with their daily doses ≥10 µmol/subject. After dosing, tanshinol, salvianolic acid D, and lithospermic acid exhibited considerable exposure in human subjects and rats. However, only tanshinol had considerable exposure in dogs. The considerable exposure to tanshinol was due to its having the highest dose, whereas that to salvianolic acid D and lithospermic acid was due to their relatively long elimination half-lives in the human subjects and rats. Protocatechuic aldehyde and rosmarinic acid circulated in the bloodstream predominantly as metabolites; salvianolic acids A and B exhibited low plasma levels with their human plasma metabolites little or not detected. Tanshinol and salvianolic acid D were eliminated mainly via renal excretion. Elimination of other catechols involved hepatobiliary and/or renal excretion of their metabolites. Methylation was found to be the primary metabolism for most Danshen catechols and showed intercompound and interspecies differences in rate and degree in vitro. The information gained here is relevant to pharmacological and toxicological research on DanHong injection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Catecóis / Salvia miltiorrhiza Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Catecóis / Salvia miltiorrhiza Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article