Institutional protocol to manage consanguinity detected by genetic testing in pregnancy in a minor.
Pediatrics
; 135(3): e736-9, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25687148
ABSTRACT
Single-nucleotide polymorphism arrays and other types of genetic tests have the potential to detect first-degree consanguinity and uncover parental rape in cases of minor teenage pregnancy. We present 2 cases in which genetic testing identified parental rape of a minor teenager. In case 1, single-nucleotide polymorphism array in a patient with multiple developmental abnormalities demonstrated multiple long stretches of homozygosity, revealing parental rape of a teenage mother. In case 2, a vague maternal sexual assault history and diagnosis of Pompe disease by direct gene sequencing identified parental rape of a minor. Given the medical, legal, and ethical implications of such revelations, a protocol was developed at our institution to manage consanguinity identified via genetic testing.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anormalidades Múltiplas
/
Testes Genéticos
/
Consanguinidade
Tipo de estudo:
Guideline
/
Prognostic_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article